ABSTRACT
Objective To investigate the clinical effects of Shenlong decoction(main ingredients consisted of ginsent root,radix polygonimultiflori,Pheretima,Ligusticum wallichii,Fructas Alpiniae oryphyllee etc.)on the treatment of cerebral vascular dementia (VD)in the elderly patients.Methods VD in all the patients(age:72.1?5.3 years old)was diagnosed according to the APA criteria, and the cerebrovascular diseases were confirmed by CT or MRI.68 patients were divided into 2 groups randomly.The experimental group consisting of 36 patients was given Chinese traditional medicine,Shenlong decoction,orally 500ml q.i.d.for 3 months,and the other 32 patients were given acetamide pyrrolidone(piracetam)orally 1.6g,tid for 3 months as a control group.The MMSE(Mini Mental State Examination)and BBS(Bless Behaviour Schedule)were used to evaluate the cognitive function and the daily activity in those patients be- fore and after treatment.Results After treatment,the scores of cognition and daily activity were improved in all the patients with VD. The effective rate in the Shenlong group was 52.8%,and 53.13% in the piracetam group.There was no significant difference in the im- provement of the short time memory and orientation ability between the two groups.However,compared with the control group,the score of daily activity was significantly improved in the Shenlong decoction group only(P
ABSTRACT
Objective To investigate the clinical significance of changes in vascular endothelial cells during the development of glucocorticoid-induced avascular necrosis of femoral head(GANFH),and the preventive and therapeutic effects of "Cugusu Keli",a mixture of traditional Chinese medicines,on GANFH in rabbit.Methods Forty-eight New Zealand white rabbits were randomly assigned to four groups,12 in each,as control group,model group,therapy group and prevention group.The contents of plasma von Willebrand's factor(vWF),6-keto-prostaglandin F1?(6-keto-PGF1?)and the activity of plasminogen activator inhibitor 1(PAI-1)were determined at the 2nd,4th,6th,8th and 12th week after treatment.Meanwhile,rabbits were sacrificed at the 4th,8th and 12th week,and both femoral heads of all rabbits were obtained for histopathological examination.Results Compared with control group,the level of vWF and activity of PAI-1 in model group were elevated since the 4th and the 2nd week,while the level of 6-keto-PGF1? increased since the 4th week(P0.05).Compared with the model group,the level of vWF and activity of PAI-1 in therapy group was lowered,while the level of 6-keto-PGF1? increased(P